- Significant Reduction in Dermatitis Severity Demonstrated
NAPLES, Fla., Nov. 18, 2021 /PRNewswire/ - Enveric Biosciences (NASDAQ: ENVB) ("Enveric" or the "Company"), a patient-centric biotechnology company developing next-generation mental health and cancer support care therapies by leveraging psychedelic-derived molecules for the mind and synthetic cannabinoids for the body, today announced that EV102, the Company's cannabidiol (CBD) based product in development for topical prescription treatment of radiodermatitis, has demonstrated significant and meaningful reduction in dermatitis severity, skin redness, and duration in a preclinical rodent model.
"Cancer patients around the world suffer the harsh side effects of various anti-cancer treatments," said Dr. Joseph Tucker, CEO of Enveric Biosciences. "Radiodermatitis, the most common side effect of radiation therapy, is a physical skin irritation with symptoms ranging from red rash to open wounds. EV102 was topically applied during a daily treatment regimen and resulted in a nearly 50% reduction in redness scoring severity. Similar results were obtained for overall dermatitis severity, which includes desquamation (skin peeling) and ulceration as part of a composite score. Extending these promising results was an observed reduction in overall duration of dermatitis symptoms." The significance of these preclinical findings will be evaluated in a planned human evaluation in 2022.
"At Enveric, we are focused on improving quality of life for cancer patients. The encouraging results of EV102 positions us to take the next steps in bringing safer and more effective prescription treatment options to market. We expect results from the preclinical study to support our efforts to move EV102 to a Phase I clinical study, targeted to begin in the second half of 2022," concluded Dr. Tucker.
Radiodermatitis (also called radiation dermatitis) is a condition caused by the high-energy X-rays delivered during radiation therapy. It affects nearly 95% of patients who receive radiation for cancer treatment, with approximately 85% of patients having moderate-to-severe skin reactions. Radiodermatitis usually begins to occur within 1-4 weeks of treatment and persists for the duration of radiation therapy. The severity of the skin reactions ranges from mild erythema (red rash) to dry desquamation (itchy, peeling skin) to the more severe moist desquamation (open wound) and severe ulceration. Radiodermatitis can be similar to the discomfort of a mild-to-severe sunburn: painful, difficult to move or wear clothing, itching, and peeling skin. In the most severe cases, ulceration can occur, disrupting the treatment.
About Enveric Biosciences
Enveric Biosciences (NASDAQ: ENVB) is an innovative biotechnology company developing a next-generation mental health and oncology treatment clinical discovery platform, leveraging psychedelic-derived molecules for the mind and synthetic cannabinoids for the body. Enveric's robust pipeline supports drug development from the clinic to commercialization for millions of patients in need around the world suffering from conditions that include cancer-related distress, PTSD and more. For more information, please visit www.enveric.com.
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